Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?

Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?

We previously described a heterozygous mouse model overexpressing human HA-tagged 24S-hydroxylase (CYP46A1) utilizing a ubiquitous expression vector. In this study, we generated homozygotes of these mice with circulating levels of 24OH 30-60% higher than the heterozygotes. Female homozygous CYP46A1...

Full description

Bibliographic Details
Main Authors:	Silvia Maioli, Ann Båvner, Zeina Ali, Maura Heverin, Muhammad-Al-Mustafa Ismail, Elena Puerta, Maria Olin, Ahmed Saeed, Marjan Shafaati, Paolo Parini, Angel Cedazo-Minguez, Ingemar Björkhem
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3712995?pdf=render

Similar Items

On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1−/− mice1
by: Zeina Ali, et al.
Published: (2013-04-01)

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1).
by: Natalia Mast, et al.
Published: (2017-01-01)

Cholesterol, oxysterol, triglyceride, and coenzyme Q homeostasis in ALS. Evidence against the hypothesis that elevated 27-hydroxycholesterol is a pathogenic factor.
by: Anna Wuolikainen, et al.
Published: (2014-01-01)

Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice.
by: Jure Acimovic, et al.
Published: (2013-01-01)

Genetic connections between neurological disorders and cholesterol metabolism
by: Ingemar Björkhem, et al.
Published: (2010-09-01)

On the substrate specificity of human CYP27A1
by: Maria Norlin, et al.
Published: (2003-08-01)

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain
by: Maura Heverin, et al.
Published: (2005-05-01)

12 alpha-hydroxylase activity in human liver and its relation to cholesterol 7 alpha-hydroxylase activity.
by: K Einarsson, et al.
Published: (1992-11-01)

The pool of free cholesterol is not of major importance for regulation of the cholesterol 7 alpha-hydroxylase activity in rat liver microsomes.
by: K Einarsson, et al.
Published: (1987-03-01)

Sex Differences in the Hepatic Cholesterol Sensing Mechanisms in Mice
by: Ingemar Björkhem, et al.
Published: (2013-09-01)

Studies on the link between HMG-CoA reductase and cholesterol 7 alpha-hydroxylase in rat liver.
by: I Björkhem, et al.
Published: (1988-02-01)

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
by: Ingemar Björkhem, et al.
Published: (1998-08-01)

Studies on the regulation of cholesterol 7 alpha-hydroxylase and HMG-CoA reductase in rat liver: effects of lymphatic drainage and ligation of the lymph duct.
by: JE Akerlund, et al.
Published: (1990-12-01)

24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome
by: Ingemar Björkhem, et al.
Published: (2018-09-01)

Bile acid synthesis in man: assay of hepatic microsomal cholesterol 7 alpha-hydroxylase activity by isotope dilution-mass spectrometry.
by: K Einarsson, et al.
Published: (1986-11-01)

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation
by: Steve Meaney, et al.
Published: (2002-12-01)

On the possible use of the serum level of 7 alpha-hydroxycholesterol as a marker for increased activity of the cholesterol 7 alpha-hydroxylase in humans
by: I Björkhem, et al.
Published: (1987-08-01)

Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis
by: Joseph B. Lin, et al.
Published: (2016-02-01)

Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7)
by: M Crestani, et al.
Published: (1995-11-01)

Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7α-hydroxy-3-oxo-4-cholestenoic acid
by: Steve Meaney, et al.
Published: (2007-04-01)

Evidence for a lack of regulatory importance of the 12 alpha-hydroxylase in formation of bile acids in man: an in vivo study.
by: I Björkhem, et al.
Published: (1983-11-01)

Hepatic cholesterol metabolism in cholesterol gallstone disease
by: E Reihnér, et al.
Published: (1991-03-01)

Novel homozygous and compound heterozygous mutations of sterol 27-hydroxylase gene (CYP27) cause cerebrotendinous xanthomatosis in three Japanese patients from two unrelated families
by: W Chen, et al.
Published: (1997-05-01)

27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial
by: Anna Sandebring-Matton, et al.
Published: (2021-03-01)

Identification of unusual 7-oxygenated bile acid sulfates in a patient with Niemann-Pick disease, type C1
by: Gunvor Alvelius, et al.
Published: (2001-10-01)

Cholesterol and ocular pathologies: focus on the role of cholesterol-24S-hydroxylase in cholesterol homeostasis
by: Fourgeux Cynthia, et al.
Published: (2015-03-01)

CYP3A Activity in End-of-Life Cancer Patients Measured by 4β-Hydroxycholesterol/cholesterol Ratio, in Men and Women
by: Helena Bergström, et al.
Published: (2021-09-01)

Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice
by: J. Wang, et al.
Published: (2006-02-01)

On the mechanism of cerebral accumulation of cholestanol in patients with cerebrotendinous xanthomatosis
by: Panzenboeck Ute, et al.
Published: (2007-05-01)

Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface
by: Lionel Bretillon, et al.
Published: (2000-05-01)

Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis
by: John Y.L. Chiang, et al.
Published: (2020-06-01)

Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprits⃞
by: Ephraim Sehayek, et al.
Published: (2006-09-01)

Effect of different dietary triglycerides on 7alpha-hydroxylation of cholesterol and other mixed-function oxidations.
by: I Björkhem, et al.
Published: (1978-03-01)

Alternate pathways of bile acid synthesis in the cholesterol 7α-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding
by: Margrit Schwarz, et al.
Published: (2001-10-01)

Identification of new mutations in sterol 27-hydroxylase gene in Japanese patients with cerebrotendinous xanthomatosis (CTX).
by: K S Kim, et al.
Published: (1994-06-01)

Pathogenic mycobacterium upregulates cholesterol 25-hydroxylase to promote granuloma development via foam cell formation
by: Shuang Zhou, et al.
Published: (2024-03-01)

Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers
by: Björkhem Ingemar, et al.
Published: (2009-08-01)

Characterization of enzymes involved in formation of ethyl esters of long-chain fatty acids in humans
by: Margareta A. Diczfalusy, et al.
Published: (2001-07-01)

Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma
by: Mingzhi Han, et al.
Published: (2020-01-01)

Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells
by: D P Wang, et al.
Published: (1996-09-01)