17-AAG-Induced Activation of the Autophagic Pathway in <i>Leishmania</i> Is Associated with Parasite Death

17-AAG-Induced Activation of the Autophagic Pathway in <i>Leishmania</i> Is Associated with Parasite Death

The heat shock protein 90 (Hsp90) is thought to be an excellent drug target against parasitic diseases. The leishmanicidal effect of an Hsp90 inhibitor, 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), was previously demonstrated in both in vitro and in vivo models of cutaneous leishmaniasis. Para...

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Bibliographic Details
Main Authors: Antonio Luis de O. A. Petersen, Benjamin Cull, Beatriz R. S. Dias, Luana C. Palma, Yasmin da S. Luz, Juliana P. B. de Menezes, Jeremy C. Mottram, Patrícia S. T. Veras
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Microorganisms
Subjects:
Hsp90
leishmaniasis
chemotherapy
Hsp90 inhibitors
autophagy
ubiquitin
Online Access:https://www.mdpi.com/2076-2607/9/5/1089

Internet

https://www.mdpi.com/2076-2607/9/5/1089

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