Peptide mimetic NC114 induces growth arrest by preventing PKCδ activation and FOXM1 nuclear translocation in colorectal cancer cells

Peptide mimetic NC114 induces growth arrest by preventing PKCδ activation and FOXM1 nuclear translocation in colorectal cancer cells

The peptide mimetic, NC114, is a promising anticancer compound that specifically kills colorectal cancer cells without affecting normal colon epithelial cells. In our previous study, we observed that NC114 inhibited the Wnt/β‐catenin pathway, with significant downregulation of both Ser 675‐phosphory...

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Bibliographic Details
Main Authors: Yuki Taguchi, Takeo Nakaya, Kenichi Aizawa, Yoshiyuki Noguchi, Nobuhiko Maiya, Chisako Iwamoto, Kenichi Ohba, Minoru Sugawara, Masayuki Murata, Ryozo Nagai, Fumi Kano
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:FEBS Open Bio
Subjects:
colorectal cancer
FOXM1
growth arrest
PKCδ
Wnt signaling
Online Access:https://doi.org/10.1002/2211-5463.13784

Internet

https://doi.org/10.1002/2211-5463.13784

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