Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients

Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients

Abstract Purpose Malignant pleural effusion (MPE) is an adverse prognostic factor in patients with osteoblastic osteosarcoma; however, the cellular contexts of MPE are largely unknown. Experimental design We performed single‐cell RNA‐sequencing (scRNA‐seq) on 27 260 cells from seven MPE samples and...

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Bibliographic Details
Main Authors: Zhichang Zhang, Weiping Ji, Jin Huang, Yawen Zhang, Yan Zhou, Jianjun Zhang, Yang Dong, Ting Yuan, Qingcheng Yang, Xiaomin Ding, Lina Tang, Hongtao Li, Junyi Yin, Yonggang Wang, Tong Ji, Jia Fei, Bing Zhang, Peizhan Chen, Haiyan Hu
Format: Article
Language:English
Published: Wiley 2022-11-01
Series:Clinical and Translational Medicine
Subjects:
malignant pleural effusion
osteoblastic osteosarcoma
primary tumour
single‐cell RNA sequencing
tumour microenvironment
Online Access:https://doi.org/10.1002/ctm2.1072

Internet

https://doi.org/10.1002/ctm2.1072

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