Therapeutic Effect of the Substrate-Selective COX-2 Inhibitor IMMA in the Animal Model of Chronic Constriction Injury

Therapeutic Effect of the Substrate-Selective COX-2 Inhibitor IMMA in the Animal Model of Chronic Constriction Injury

Enhancement of endocannabinoid signaling has emerged as an attractive strategy for the treatment of pain. In addition to the well-characterized hydrolytic pathways, cyclooxygenase-2 (COX-2) mediated oxygenation is thought to be an alternative route for endocannabinoid metabolism and therefore provid...

Full description

Bibliographic Details
Main Authors: Melissa Jones, Jie Wen, Prabhuanand Selvaraj, Mikiei Tanaka, Sean Moran, Yumin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Pharmacology
Subjects:
substrate-selective COX-2 inhibitor
endocannabinoids
CB2 receptors
PGE2
chronic constriction injury
neuropathic pain
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01481/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01481/full

Similar Items