Insights into Allosteric Mechanisms of the Lung-Enriched p53 Mutants V157F and R158L

Insights into Allosteric Mechanisms of the Lung-Enriched p53 Mutants V157F and R158L

Lung cancer is a leading fatal malignancy in humans. p53 mutants exhibit not only loss of tumor suppressor capability but also oncogenic gain-of-function, contributing to lung cancer initiation, progression and therapeutic resistance. Research shows that p53 mutants V157F and R158L occur with high f...

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Bibliographic Details
Main Authors: Jiangtao Lei, Xuanyao Li, Mengqiang Cai, Tianjing Guo, Dongdong Lin, Xiaohua Deng, Yin Li
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
p53
V157F mutant
R158L mutant
allosteric mechanism
molecule dynamic simulation
Online Access:https://www.mdpi.com/1422-0067/23/17/10100

Internet

https://www.mdpi.com/1422-0067/23/17/10100

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