Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

Abstract Background Cancer stem cell (CSC) is identified in osteosarcoma (OS) and considered resistant to chemotherapeutic agents. However, the mechanism of osteosarcoma stem cell (OSC) resistant to chemotherapy remains debatable and vague, and the metabolomics feature of OSC is not clarified. Mater...

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Bibliographic Details
Main Authors: Feng Wang, Zhiyu Zhang, Qin Li, Tao Yu, Chengbin Ma
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Cancer Cell International
Subjects:
Osteosarcoma (OS)
Cancer stem cell (CSC)
Chemo-resistance
Metabolomics
Methotrexate (MTX)
Online Access:http://link.springer.com/article/10.1186/s12935-020-01356-y

Internet

http://link.springer.com/article/10.1186/s12935-020-01356-y

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