Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets
Roll compaction was applied for the preparation of hydroxypropyl cellulose (HPC)-based sustained-release matrix tablets. Matrix tablets made via roll compaction exhibited higher dosage uniformity and faster drug release than direct-compacted tablets. HPC viscosity grade, roll pressure, and milling s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=2;spage=213;epage=220;aulast=Jeon |
| _version_ | 1818303239188119552 |
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| author | Imjak Jeon Tiziana Gilli Gabriele Betz |
| author_facet | Imjak Jeon Tiziana Gilli Gabriele Betz |
| author_sort | Imjak Jeon |
| collection | DOAJ |
| description | Roll compaction was applied for the preparation of hydroxypropyl cellulose (HPC)-based sustained-release matrix tablets. Matrix tablets made via roll compaction exhibited higher dosage uniformity and faster drug release than direct-compacted tablets. HPC viscosity grade, roll pressure, and milling speed affected tablet properties significantly. Roll compaction seems to be an adequate granulation method for the preparation of HPC-based matrix tablets due to the simplicity of the process, less handling difficulty from HPC tackiness as well as easier particle size targeting. Selecting the optimum ratio of plastic excipients and the particle size of starting materials can however be critical issues in this method. |
| first_indexed | 2024-12-13T05:51:38Z |
| format | Article |
| id | doaj.art-300580daaa6841b59cac7f6a921726d2 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 0976-4879 |
| language | English |
| last_indexed | 2024-12-13T05:51:38Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-300580daaa6841b59cac7f6a921726d22022-12-21T23:57:32ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74060976-48792011-01-013221322010.4103/0975-7406.80771Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tabletsImjak JeonTiziana GilliGabriele BetzRoll compaction was applied for the preparation of hydroxypropyl cellulose (HPC)-based sustained-release matrix tablets. Matrix tablets made via roll compaction exhibited higher dosage uniformity and faster drug release than direct-compacted tablets. HPC viscosity grade, roll pressure, and milling speed affected tablet properties significantly. Roll compaction seems to be an adequate granulation method for the preparation of HPC-based matrix tablets due to the simplicity of the process, less handling difficulty from HPC tackiness as well as easier particle size targeting. Selecting the optimum ratio of plastic excipients and the particle size of starting materials can however be critical issues in this method.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=2;spage=213;epage=220;aulast=JeonDry granulationhydroxypropyl cellulosematrix tabletroll compactionsustained release |
| spellingShingle | Imjak Jeon Tiziana Gilli Gabriele Betz Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets Journal of Pharmacy and Bioallied Sciences Dry granulation hydroxypropyl cellulose matrix tablet roll compaction sustained release |
| title | Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets |
| title_full | Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets |
| title_fullStr | Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets |
| title_full_unstemmed | Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets |
| title_short | Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets |
| title_sort | evaluation of roll compaction as a preparation method for hydroxypropyl cellulose based matrix tablets |
| topic | Dry granulation hydroxypropyl cellulose matrix tablet roll compaction sustained release |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=2;spage=213;epage=220;aulast=Jeon |
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