Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells.

Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells.

Phosphorylation of sphingosine by sphingosine kinases (SphK1 and SphK2) generates sphingosine-1-phosphate (S1P), a bioactive sphingolipid which promotes cancer cell survival and tumor progression in vivo. We have recently reported that targeting SphK2 induces apoptosis for human primary effusion lym...

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Bibliographic Details
Main Authors: Lu Dai, Karlie Plaisance-Bonstaff, Christina Voelkel-Johnson, Charles D Smith, Besim Ogretmen, Zhiqiang Qin, Chris Parsons
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4092155?pdf=render

Internet

http://europepmc.org/articles/PMC4092155?pdf=render

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