All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling

All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling

Abstract Background and purpose Regulation of neural inflammation is considered as a vital therapeutic target in ischemic stroke. All-trans retinoic acid (atRA), a potent immune modulator, has raised interest in the field of stroke therapy. However, the immunological mechanisms for atRA-mediated neu...

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Bibliographic Details
Main Authors: Wei Cai, Julie Wang, Mengyan Hu, Xiao Chen, Zhengqi Lu, Joseph A. Bellanti, Song Guo Zheng
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Neuroinflammation
Subjects:
Cerebral ischemia
Neutrophil
Neural inflammation
All trans-retinoic acid
Neuroprotection
Online Access:http://link.springer.com/article/10.1186/s12974-019-1557-6

Internet

http://link.springer.com/article/10.1186/s12974-019-1557-6

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