Kourami: graph-guided assembly for novel human leukocyte antigen allele discovery

Abstract Accurate typing of human leukocyte antigen (HLA) is important because HLA genes play important roles in immune responses and disease genesis. Previously available computational methods are database-matching approaches and their outputs are inherently limited by the completeness of already k...

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Bibliographic Details
Main Authors: Heewook Lee, Carl Kingsford
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Genome Biology
Online Access:http://link.springer.com/article/10.1186/s13059-018-1388-2