Development of a thiostrepton-free system for stable production of PLD in Streptomyces lividans SBT5

Development of a thiostrepton-free system for stable production of PLD in Streptomyces lividans SBT5

Abstract Background Phospholipase D (PLD) is highly valuable in the food and medicine industries, where it is used to convert low-cost phosphatidylcholine into high-value phospholipids (PLs). Despite being overexpressed in Streptomyces, PLD production requires expensive thiostrepton feeding during f...

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Bibliographic Details
Main Authors: Juntan Wang, Haihua Zhu, Huiyi Shang, Bishan Guo, Mengxue Zhang, Fayun Wang, Lipan Zhang, Jun Xu, Hui Wang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Microbial Cell Factories
Subjects:
Phospholipase D
Streptomyces
Expression system
Thiostrepton
Plasmid stability
Online Access:https://doi.org/10.1186/s12934-022-01992-1

Internet

https://doi.org/10.1186/s12934-022-01992-1

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