Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients

Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients

Abstract Background Bilateral breast cancer (BBC), as well as ovarian cancer, are significantly associated with germline deleterious variants in BRCA1/2, while BRCA1/2 germline deleterious variants carriers can exquisitely benefit from poly (ADP-ribose) polymerase (PARP) inhibitors. However, formal...

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Bibliographic Details
Main Authors: Yan Li, Lili Chen, Jinxing Lv, Xiaobin Chen, Bangwei Zeng, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Jing Li, Peng Zhou, Wenzhe Zhang, Shengmei Li, Xuan Jin, Weifeng Cai, Kun Zhang, Yeyuan Huang, Chuan Wang, Fangmeng Fu
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Cancer
Subjects:
Bilateral breast cancer
BRCA1
BRCA2
Germline deleterious variant
Artificial neural network
Online Access:https://doi.org/10.1186/s12885-022-10160-y

Internet

https://doi.org/10.1186/s12885-022-10160-y

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