Multi-Target Directed Ligands (MTDLs) Binding the σ<sub>1</sub> Receptor as Promising Therapeutics: State of the Art and Perspectives

Multi-Target Directed Ligands (MTDLs) Binding the σ<sub>1</sub> Receptor as Promising Therapeutics: State of the Art and Perspectives

The sigma-1 (σ<sub>1</sub>) receptor is a ‘pluripotent chaperone’ protein mainly expressed at the mitochondria–endoplasmic reticulum membrane interfaces where it interacts with several client proteins. This feature renders the σ<sub>1</sub> receptor an ideal target for the de...

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Bibliographic Details
Main Authors: Francesca Serena Abatematteo, Mauro Niso, Marialessandra Contino, Marcello Leopoldo, Carmen Abate
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
sigma receptors
sigma-1 receptor
multi-target directed ligands (MTDLs)
sigma-1 ligands
polypharmacology
Online Access:https://www.mdpi.com/1422-0067/22/12/6359

Internet

https://www.mdpi.com/1422-0067/22/12/6359

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