Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists

Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists

P2X receptors are extracellular ATP-gated ion channels that form homo- or heterotrimers and consist of seven subtypes. They are expressed in various tissues, including neuronal and nonneuronal cells, and play critical roles in physiological processes such as neurotransmission, inflammation, pain, an...

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Bibliographic Details
Main Authors: Danqi Sheng, Chen-Xi Yue, Fei Jin, Yao Wang, Muneyoshi Ichikawa, Ye Yu, Chang-Run Guo, Motoyuki Hattori
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-04-01
Series:eLife
Subjects:
membrane channels
receptors
electron microscopy
electrophysiology
Online Access:https://elifesciences.org/articles/92829

Internet

https://elifesciences.org/articles/92829

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