Development of a Fragment-Based Screening Assay for the Focal Adhesion Targeting Domain Using SPR and NMR

Development of a Fragment-Based Screening Assay for the Focal Adhesion Targeting Domain Using SPR and NMR

The Focal Adhesion Targeting (FAT) domain of Focal Adhesion Kinase (FAK) is a promising drug target since FAK is overexpressed in many malignancies and promotes cancer cell metastasis. The FAT domain serves as a scaffolding protein, and its interaction with the protein paxillin localizes FAK to foca...

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Bibliographic Details
Main Authors: Carlos Alvarado, Erik Stahl, Karissa Koessel, Andrew Rivera, Brian R. Cherry, Surya V.S.R.K. Pulavarti, Thomas Szyperski, William Cance, Timothy Marlowe
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
focal adhesion kinase
FAT domain
fragment-based drug discovery
surface plasmon resonance
nuclear magnetic resonance
Online Access:https://www.mdpi.com/1420-3049/24/18/3352

Internet

https://www.mdpi.com/1420-3049/24/18/3352

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