Cough Aerosol Cultures of Mycobacterium tuberculosis: Insights on TST / IGRA Discordance and Transmission Dynamics.

The diagnosis of latent tuberculosis (TB) infection (LTBI) is complicated by the absence of a gold standard. Discordance between tuberculin skin tests (TST) and interferon gamma release assays (IGRA) occurs in 10-20% of individuals, but the underlying mechanisms are poorly understood.We analyzed dat...

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Main Authors: Edward C Jones-López, Laura F White, Bruce Kirenga, Francis Mumbowa, Martin Ssebidandi, Stephanie Moine, Olive Mbabazi, Gerald Mboowa, Irene Ayakaka, Soyeon Kim, Christina S Thornton, Alphonse Okwera, Moses Joloba, Kevin P Fennelly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4578948?pdf=render