Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors

Hedgehog-GLI (HH) signaling was originally identified as a critical morphogenetic pathway in embryonic development. Since its discovery, a multitude of studies have reported that HH signaling also plays key roles in a variety of cancer types and in maintaining tumor-initiating cells. Smoothened (SMO...

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Bibliographic Details
Main Authors: Silvia Pietrobono, Barbara Stecca
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cells
Subjects:
hedgehog
smoothened
missense mutations
small molecule inhibitors
GLI
cancer
targeted therapy
drug-resistance
acylguanidine derivative
Online Access:https://www.mdpi.com/2073-4409/7/12/272

Internet

https://www.mdpi.com/2073-4409/7/12/272

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