YH29407 with anti-PD-1 ameliorates anti-tumor effects via increased T cell functionality and antigen presenting machinery in the tumor microenvironment

YH29407 with anti-PD-1 ameliorates anti-tumor effects via increased T cell functionality and antigen presenting machinery in the tumor microenvironment

Among cancer cells, indoleamine 2, 3-dioxygenase1 (IDO1) activity has been implicated in improving the proliferation and growth of cancer cells and suppressing immune cell activity. IDO1 is also responsible for the catabolism of tryptophan to kynurenine. Depletion of tryptophan and an increase in ky...

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Bibliographic Details
Main Authors: Dong Kwon Kim, Chun-Bong Synn, Seung Min Yang, Seongsan Kang, Sujeong Baek, Se-Woong Oh, Gyu-Jin Lee, Ho-Woong Kang, Young-Sung Lee, Jong Suk Park, Jae Hwan Kim, Youngseon Byeon, Young Seob Kim, Doo Jae Lee, Hyun-Woo Kim, June Dong Park, Sung Sook Lee, Ji Yun Lee, Jii Bum Lee, Chang Gon Kim, Min Hee Hong, Sun Min Lim, Hey Ryun Kim, Kyoung-Ho Pyo, Byoung Chul Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Chemistry
Subjects:
IDO1
tryptophan
kynurenine
molecule inhibitor
colon cancer
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.998013/full

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https://www.frontiersin.org/articles/10.3389/fchem.2022.998013/full

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