Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches

Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches

Bibliographic Details
Main Authors: Tomohiro Sato, Katsuhiko Sekimata, Naoki Sakai, Hisami Watanabe, Chiemi Mishima-Tsumagari, Tomonori Taguri, Takehisa Matsumoto, Yoshifumi Fujii, Noriko Handa, Akiko Tanaka, Mikako Shirouzu, Shigeyuki Yokoyama, Yoshinobu Hashizume, Kohei Miyazono, Hiroo Koyama, Teruki Honma
Format: Article
Language:English
Published: American Chemical Society 2020-05-01
Series:ACS Omega
Online Access:https://doi.org/10.1021/acsomega.9b04245

Internet

https://doi.org/10.1021/acsomega.9b04245

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