Production of bioactive liver-targeting interferon Mu-IFN-CSP by soluble prokaryotic expression

Production of bioactive liver-targeting interferon Mu-IFN-CSP by soluble prokaryotic expression

Abstract A novel liver-targeting interferon (IFN-CSP) was successfully over-expressed in our previous work. The in vitro and in vivo investigation revealed that IFN-CSP has significant anti-hepatitis B virus (HBV) effect and liver-targeting capacity. However, due to the IFN-CSP tends to form inclusi...

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Bibliographic Details
Main Authors: Along Liu, Shuiqing Gui, Lun Zhang, Zhaoxia Chen, Yanan Tang, Mingzhu Xiao, Jie Wang, Wenbin Liu, Xiaobao Jin, Jiayong Zhu, Xuemei Lu
Format: Article
Language:English
Published: SpringerOpen 2017-10-01
Series:AMB Express
Subjects:
Liver-targeting interferon
Amino acid mutant
Preferred codon optimized
Escherichia coli
Soluble expression
Expression conditions optimized
Online Access:http://link.springer.com/article/10.1186/s13568-017-0493-z

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http://link.springer.com/article/10.1186/s13568-017-0493-z

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