Physical exercise regulates p53 activity targeting SCO2 and increases mitochondrial COX biogenesis in cardiac muscle with age.

Physical exercise regulates p53 activity targeting SCO2 and increases mitochondrial COX biogenesis in cardiac muscle with age.

The purpose of this study was to outline the timelines of mitochondrial function, oxidative stress and cytochrome c oxidase complex (COX) biogenesis in cardiac muscle with age, and to evaluate whether and how these age-related changes were attenuated by exercise. ICR/CD-1 mice were treated with pifi...

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Bibliographic Details
Main Authors: Zhengtang Qi, Jie He, Yuhui Su, Qiang He, Jingxia Liu, Lu Yu, Omar Al-Attas, Tajamul Hussain, Shuzhe Ding, Liu Ji, Min Qian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21750704/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21750704/?tool=EBI

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