Protease activities of vaginal Porphyromonas species disrupt coagulation and extracellular matrix in the cervicovaginal niche

Abstract Porphyromonas asaccharolytica and Porphyromonas uenonis are common inhabitants of the vaginal microbiome, but their presence has been linked to adverse health outcomes for women, including bacterial vaginosis and preterm birth. However, little is known about the pathogenesis mechanisms of t...

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Bibliographic Details
Main Authors: Karen V. Lithgow, Vienna C. H. Buchholz, Emily Ku, Shaelen Konschuh, Ana D’Aubeterre, Laura K. Sycuro
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-022-00270-7