Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones

Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones

Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacteriophage DNA. To counteract the latter activity, bacteriopha...

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Bibliographic Details
Main Authors: Martin Wilkinson, Luca A Troman, Wan AK Wan Nur Ismah, Yuriy Chaban, Matthew B Avison, Mark S Dillingham, Dale B Wigley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
DNA repair
RecBCD
antibacterials
Online Access:https://elifesciences.org/articles/22963

Internet

https://elifesciences.org/articles/22963

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