Active site mutations change the cleavage specificity of neprilysin.
Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides. We have generated a series of neprilysin variants containing mutations at either one of two active site residues, Phe(563)...
| Autores principales: | , , , , |
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| Formato: | Artículo |
| Lenguaje: | English |
| Publicado: |
Public Library of Science (PLoS)
2012-01-01
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| Colección: | PLoS ONE |
| Acceso en línea: | http://europepmc.org/articles/PMC3285688?pdf=render |