Activation of the Nrf2/ARE signaling pathway protects against palmitic acid-induced renal tubular epithelial cell injury by ameliorating mitochondrial reactive oxygen species-mediated mitochondrial dysfunction

Activation of the Nrf2/ARE signaling pathway protects against palmitic acid-induced renal tubular epithelial cell injury by ameliorating mitochondrial reactive oxygen species-mediated mitochondrial dysfunction

Chronic kidney disease (CKD) is often accompanied by dyslipidemia, and abnormal lipid metabolism in proximal tubule cells is considered closely related to the dysfunction of proximal tubule cells and eventually leads to accelerated kidney damage. Nuclear factor E2-related factor 2 (Nrf2), known as a...

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Bibliographic Details
Main Authors: Xu-shun Jiang, Meng-yao Cai, Xun-jia Li, Qing Zhong, Man-li Li, Yun-feng Xia, Qing Shen, Xiao-gang Du, Hua Gan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Medicine
Subjects:
Nrf2
palmitic acid
mitochondrial ROS
mitochondrial dysfunction
renal tubular epithelial cell
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.939149/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.939149/full

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