High-Fat, High-Calorie Diet Enhances Mammary Carcinogenesis and Local Inflammation in MMTV-PyMT Mouse Model of Breast Cancer

High-Fat, High-Calorie Diet Enhances Mammary Carcinogenesis and Local Inflammation in MMTV-PyMT Mouse Model of Breast Cancer

Epidemiological studies provide strong evidence that obesity and the associated adipose tissue inflammation are risk factors for breast cancer; however, the molecular mechanisms are poorly understood. We evaluated the effect of a high-fat/high-calorie diet on mammary carcinogenesis in the immunocomp...

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Bibliographic Details
Main Authors: Sarah Cowen, Sarah L. McLaughlin, Gerald Hobbs, James Coad, Karen H. Martin, I. Mark Olfert, Linda Vona-Davis
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Cancers
Subjects:
obesity
high-fat diet
inflammation
angiogenesis
tumor progression
Online Access:http://www.mdpi.com/2072-6694/7/3/0828

Internet

http://www.mdpi.com/2072-6694/7/3/0828

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