Rescue of impaired blood-brain barrier in tuberous sclerosis complex patient derived neurovascular unit

Rescue of impaired blood-brain barrier in tuberous sclerosis complex patient derived neurovascular unit

Abstract Background Tuberous sclerosis complex (TSC) is a multi-system genetic disease that causes benign tumors in the brain and other vital organs. The most debilitating symptoms result from involvement of the central nervous system and lead to a multitude of severe symptoms including seizures, in...

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Bibliographic Details
Main Authors: Jacquelyn A. Brown, Shannon L. Faley, Monika Judge, Patricia Ward, Rebecca A. Ihrie, Robert Carson, Laura Armstrong, Mustafa Sahin, John P. Wikswo, Kevin C. Ess, M. Diana Neely
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
BBB
Human stem cells
Astrocytes
mTOR
Rapamycin
Microfluidics
Online Access:https://doi.org/10.1186/s11689-024-09543-y

Internet

https://doi.org/10.1186/s11689-024-09543-y

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