Enhanced DNA and RNA pathogen detection via metagenomic sequencing in patients with pneumonia

Enhanced DNA and RNA pathogen detection via metagenomic sequencing in patients with pneumonia

Abstract Background Metagenomic next-generation sequencing (mNGS) is an important supplement to conventional tests for pathogen detections of pneumonia. However, mNGS pipelines were limited by irregularities, high proportion of host nucleic acids, and lack of RNA virus detection. Thus, a regulated p...

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Bibliographic Details
Main Authors: Yukun He, Kechi Fang, Xing Shi, Donghong Yang, Lili Zhao, Wenyi Yu, Yali Zheng, Yu Xu, Xinqian Ma, Li Chen, Yu Xie, Yan Yu, Jing Wang, Zhancheng Gao
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Translational Medicine
Subjects:
Pneumonia
Metagenomic next-generation sequencing
Early pathogen detection
Online Access:https://doi.org/10.1186/s12967-022-03397-5

Internet

https://doi.org/10.1186/s12967-022-03397-5

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