Post-Translational Modifications of G Protein–Coupled Receptors Revealed by Proteomics and Structural Biology

Post-Translational Modifications of G Protein–Coupled Receptors Revealed by Proteomics and Structural Biology

G protein–coupled receptors (GPCRs) are a protein superfamily comprising >800 members that regulate numerous cellular and physiologic responses. GPCRs represent the largest class of therapeutic targets with implications in various diseases. Although advances in GPCR structural and pharmacolog...

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Bibliographic Details
Main Authors: Bingjie Zhang, Shanshan Li, Wenqing Shui
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Chemistry
Subjects:
G protein couped receptors
mass spectrometry-based proteomics
Post-translational modification (PTM)
phosphorylation
signaling regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.843502/full

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https://www.frontiersin.org/articles/10.3389/fchem.2022.843502/full

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