Canagliflozin inhibits PASMCs proliferation via regulating SGLT1/AMPK signaling and attenuates artery remodeling in MCT-induced pulmonary arterial hypertension

Canagliflozin inhibits PASMCs proliferation via regulating SGLT1/AMPK signaling and attenuates artery remodeling in MCT-induced pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) was a devastating disease characterized by artery remodeling, ultimately resulting in right heart failure. The aim of this study was to investigate the effects of canagliflozin (CANA), a sodium-glucose cotransporter 2 inhibitor (SGLT2i) with mild SGLT1 inhibitor...

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Bibliographic Details
Main Authors: Xiaojun Chen, Xing Yu, Guili Lian, Huibin Tang, Yan Yan, Gufeng Gao, Bangbang Huang, Li Luo, Liangdi Xie
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Canagliflozin
Pulmonary arterial hypertension
SGLT2 inhibitors
Proliferation
SGLT1
AMPK
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224003895

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http://www.sciencedirect.com/science/article/pii/S0753332224003895

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