Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation

Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation

Tcf7l2 mediates Wnt/β-Catenin signalling during development and is implicated in cancer and type-2 diabetes. The mechanisms by which Tcf7l2 and Wnt/β-Catenin signalling elicit such a diversity of biological outcomes are poorly understood. Here, we study the function of zebrafish tcf7l2 alternative s...

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Bibliographic Details
Main Authors: Rodrigo M Young, Kenneth B Ewan, Veronica P Ferrer, Miguel L Allende, Jasminka Godovac-Zimmermann, Trevor C Dale, Stephen W Wilson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
alternative splicing
tcf7l2
zebrafish
eye development
Online Access:https://elifesciences.org/articles/51447

Internet

https://elifesciences.org/articles/51447

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