Fenofibrate Recognition and Gq Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1

Fenofibrate Recognition and Gq Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1

Abstract The G‐protein‐coupled human cannabinoid receptor 1 (CB1) is a promising therapeutic target for pain management, inflammation, obesity, and substance abuse disorders. The structures of CB1‐Gi complexes in synthetic agonist‐bound forms have been resolved to date. However, the commercial drug...

Full description

Bibliographic Details
Main Authors: Tianxin Wang, Wenqin Tang, Ziyi Zhao, Ran Zhao, Zhenyu Lv, Xuzhen Guo, Quanchang Gu, Boxiang Liu, Haoyu Lv, Jiayan Chen, Kaiquan Zhang, Fahui Li, Jiangyun Wang
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Advanced Science
Subjects:
cryo‐electron microscopy
fenofibrate
Gq coupling
human cannabinoid receptor 1
ligand recognition
Online Access:https://doi.org/10.1002/advs.202306311

Internet

https://doi.org/10.1002/advs.202306311

Similar Items