Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification

Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification

Recent studies have shown that zinc finger nucleases (ZFNs) are powerful reagents for making site-specific genomic modifications. The generic structure of these enzymes includes a ZF DNA-binding domain and nuclease domain (Fn) are separated by an amino acid “linker” and cut genomic DNA at sites that...

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Bibliographic Details
Main Authors: Kimberly A Wilson, Abbye E McEwen, Shondra M Pruett-Miller, Jiuli Zhang, Eric J Kildebeck, Matthew H Porteus
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
genomic modification
inter-domain linker
inter-finger linker
zinc finger
zinc finger nuclease
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301445

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http://www.sciencedirect.com/science/article/pii/S2162253116301445

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