Puerarin inhibited oxidative stress and alleviated cerebral ischemia-reperfusion injury through PI3K/Akt/Nrf2 signaling pathway

Puerarin inhibited oxidative stress and alleviated cerebral ischemia-reperfusion injury through PI3K/Akt/Nrf2 signaling pathway

Introduction: Puerarin (PUE) is a natural compound isolated from Puerariae Lobatae Radix, which has a neuroprotective effect on IS. We explored the therapeutic effect and underlying mechanism of PUE on cerebral I/R injury by inhibiting oxidative stress related to the PI3K/Akt/Nrf2 pathway in vitro a...

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Bibliographic Details
Main Authors: Qianqian Zhang, Min Yao, Jiajia Qi, Rui Song, Lei Wang, Jiacheng Li, Xian Zhou, Dennis Chang, Qi Huang, Lili Li, Ning Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
cerebral ischemia reperfusion injury (CIRI)
puerarin
hippocampal neurons
oxidative stress
PI3K/Akt/Nrf2 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1134380/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1134380/full

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