High Glucose Impairs Expression and Activation of MerTK in ARPE-19 Cells

High Glucose Impairs Expression and Activation of MerTK in ARPE-19 Cells

MerTK (Mer Tyrosine Kinase) is a cell surface receptor that regulates phagocytosis of photoreceptor outer segments (POS) in retinal pigment epithelial (RPE) cells. POS phagocytosis is impaired in several pathologies, including diabetes. In this study, we investigate whether hyperglycemic conditions...

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Bibliographic Details
Main Authors: Alessandra Puddu, Silvia Ravera, Isabella Panfoli, Nadia Bertola, Davide Maggi
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
MerTK
ARPE-19 cells
diabetes
ADAM9
miR-126
phagocytosis
Online Access:https://www.mdpi.com/1422-0067/23/3/1144

Internet

https://www.mdpi.com/1422-0067/23/3/1144

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