Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis

Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis

Demyelination and axonal injury are the key pathological processes in multiple sclerosis (MS), driven by inflammation and oxidative stress. Acrolein, a byproduct and instigator of oxidative stress, has been demonstrated as a neurotoxin in experimental autoimmune encephalomyelitis (EAE), an animal mo...

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Bibliographic Details
Main Authors: Melissa Tully, Jonathan Tang, Lingxing Zheng, Glen Acosta, Ran Tian, Lee Hayward, Nicholas Race, David Mattson, Riyi Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Neurology
Subjects:
oxidative stress
3-HPMA
aldehyde
inflammation
lipid peroxidation
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00420/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.00420/full

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