Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis
Demyelination and axonal injury are the key pathological processes in multiple sclerosis (MS), driven by inflammation and oxidative stress. Acrolein, a byproduct and instigator of oxidative stress, has been demonstrated as a neurotoxin in experimental autoimmune encephalomyelitis (EAE), an animal mo...
Main Authors: | Melissa Tully, Jonathan Tang, Lingxing Zheng, Glen Acosta, Ran Tian, Lee Hayward, Nicholas Race, David Mattson, Riyi Shi |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-06-01
|
Series: | Frontiers in Neurology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00420/full |
Similar Items
-
Critical role of mitochondrial aldehyde dehydrogenase 2 in acrolein sequestering in rat spinal cord injury
by: Seth A Herr, et al.
Published: (2022-01-01) -
Neuroprotection by acrolein sequestration through exogenously applied scavengers and endogenous enzymatic enabling strategies in mouse EAE model
by: Jonathan Tang, et al.
Published: (2024-03-01) -
Chitosan nanoparticle-based neuronal membrane sealing and neuroprotection following acrolein-induced cell injury
by: Shi Riyi, et al.
Published: (2010-01-01) -
DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity
by: Fabrizio Gentile, et al.
Published: (2017-04-01) -
Capsid and Genome Modification Strategies to Reduce the Immunogenicity of Adenoviral Vectors
by: Florian Kreppel, et al.
Published: (2021-02-01)