Beyond the Biosynthetic Gene Cluster Paradigm: Genome-Wide Coexpression Networks Connect Clustered and Unclustered Transcription Factors to Secondary Metabolic Pathways

Beyond the Biosynthetic Gene Cluster Paradigm: Genome-Wide Coexpression Networks Connect Clustered and Unclustered Transcription Factors to Secondary Metabolic Pathways

ABSTRACT Fungal secondary metabolites are widely used as therapeutics and are vital components of drug discovery programs. A major challenge hindering discovery of novel secondary metabolites is that the underlying pathways involved in their biosynthesis are transcriptionally silent under typical la...

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Bibliographic Details
Main Authors: Min Jin Kwon, Charlotte Steiniger, Timothy C. Cairns, Jennifer H. Wisecaver, Abigail L. Lind, Carsten Pohl, Carmen Regner, Antonis Rokas, Vera Meyer
Format: Article
Language:English
Published: American Society for Microbiology 2021-10-01
Series:Microbiology Spectrum
Subjects:
filamentous fungi
Aspergillus niger
secondary metabolite gene clusters
gene coexpression
correlation network
natural product
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00898-21

Internet

https://journals.asm.org/doi/10.1128/Spectrum.00898-21

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