Different rates of flux through the biosynthetic pathway for long-chain versus very-long-chain sphingolipids

The backbone of all sphingolipids (SLs) is a sphingoid long-chain base (LCB) to which a fatty acid is N-acylated. Considerable variability exists in the chain length and degree of saturation of both of these hydrophobic chains, and recent work has implicated ceramides with different LCBs and N-acyl...

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Bibliographic Details
Main Authors: Iris D. Zelnik, Giora Volpert, Leena E. Viiri, Dimple Kauhanen, Tamar Arazi, Katriina Aalto-Setälä, Reijo Laaksonen, Anthony H. Futerman
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520437010