Accurate prediction of secreted substrates and identification of a conserved putative secretion signal for type III secretion systems.

The type III secretion system is an essential component for virulence in many Gram-negative bacteria. Though components of the secretion system apparatus are conserved, its substrates--effector proteins--are not. We have used a novel computational approach to confidently identify new secreted effect...

Full description

Bibliographic Details
Main Authors: Ram Samudrala, Fred Heffron, Jason E McDermott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2668754?pdf=render