Molecular mechanisms involved in the IL-6-mediated upregulation of indoleamine 2,3-dioxygenase 1 (IDO1) expression in the chorionic villi and decidua of women in early pregnancy

Abstract Background IL-6 induces the upregulation of indoleamine 2,3-dioxygenase (IDO1) at the maternal-foetal interface, but the regulation mechanisms of IDO1 by IL-6 at this interface have not been fully understood. Methods Western blotting, qRT–PCR and/or immunohistochemistry were employed to mea...

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Bibliographic Details
Main Authors: Rui Wang, Shuyun Zhao, Xiaojuan Chen, Ziwen Xiao, Xinghui Wen, Xingming Zhong, Shixiang Li, Hui Cheng, Guanyou Huang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Pregnancy and Childbirth
Subjects:
Online Access:https://doi.org/10.1186/s12884-022-05307-5