T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

CD4+ T-helper cells play an important role in alloimmune reactions following transplantation by stimulating humoral as well as cellular responses, which might lead to failure of the allograft. CD4+ memory T-helper cells from a previous immunizing event can potentially be reactivated by exposure to H...

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Main Authors: Emma T. M. Peereboom, Benedict M. Matern, Toshihide Tomosugi, Matthias Niemann, Julia Drylewicz, Irma Joosten, Wil A. Allebes, Arnold van der Meer, Luuk B. Hilbrands, Marije C. Baas, Franka E. van Reekum, Marianne C. Verhaar, Elena G. Kamburova, Marc A. J. Seelen, Jan Stephan Sanders, Bouke G. Hepkema, Annechien J. Lambeck, Laura B. Bungener, Caroline Roozendaal, Marcel G. J. Tilanus, Christien E. Voorter, Lotte Wieten, Elly M. van Duijnhoven, Mariëlle A. C. J. Gelens, Maarten H. L. Christiaans, Frans J. van Ittersum, Azam Nurmohamed, Neubury M. Lardy, Wendy Swelsen, Karlijn A. van der Pant, Neelke C. van der Weerd, Ineke J. M. ten Berge, Fréderike J. Bemelman, Aiko P. J. de Vries, Johan W. de Fijter, Michiel G. H. Betjes, Dave L. Roelen, Frans H. Claas, Henny G. Otten, Sebastiaan Heidt, Arjan D. van Zuilen, Takaaki Kobayashi, Kirsten Geneugelijk, Eric Spierings
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
HLA antigens
PIRCHE-II
graft failure
kidney transplantation
shared T-cell epitopes
T-cell epitope
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.784040/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.784040/full

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