Effect of low-to-moderate hyperoxia on lung injury in preclinical animal models: a systematic review and meta-analysis

Effect of low-to-moderate hyperoxia on lung injury in preclinical animal models: a systematic review and meta-analysis

Abstract Background Extensive animal investigation informed clinical practice regarding the harmful effects of high fractional inspired oxygen concentrations (FiO2s > 0.60). Since questions persist whether lower but still supraphysiologic FiO2 ≤ 0.60 and > 0.21 (FiO2 ≤ 0.60/ > 0.21) are als...

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Bibliographic Details
Main Authors: Samuel Minkove, Rhea Dhamapurkar, Xizhong Cui, Yan Li, Junfeng Sun, Diane Cooper, Peter Q. Eichacker, Parizad Torabi-Parizi
Format: Article
Language:English
Published: SpringerOpen 2023-04-01
Series:Intensive Care Medicine Experimental
Subjects:
Oxygen toxicity
Oxygen therapy
Animal models
Inflammatory lung injury
Online Access:https://doi.org/10.1186/s40635-023-00501-x

Internet

https://doi.org/10.1186/s40635-023-00501-x

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