Evaluation of Anticancer Activity of Nucleoside–Nitric Oxide Photo-Donor Hybrids

Evaluation of Anticancer Activity of Nucleoside–Nitric Oxide Photo-Donor Hybrids

Herein, we report the synthesis of a new hybrid compound based on a 2′-deoxyuridine nucleoside conjugated with a NO photo-donor moiety (dU-t-NO) via CuAAC click chemistry. Hybrid dU-t-NO, as well as two previously reported 2′-deoxyadenosine based hybrids (dAdo-S-NO and dAdo-t-NO), were evaluated for...

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Bibliographic Details
Main Authors: Elena Marchesi, Elisabetta Melloni, Fabio Casciano, Elena Pozza, Roberto Argazzi, Carmela De Risi, Lorenzo Preti, Daniela Perrone, Maria Luisa Navacchia
Format: Article
Language:English
Published: MDPI AG 2024-07-01
Series:Molecules
Subjects:
nucleoside analogs
hybrid drugs
nitric oxide
photo-donor
anticancer activity
multitarget anticancer drugs
Online Access:https://www.mdpi.com/1420-3049/29/14/3383

Internet

https://www.mdpi.com/1420-3049/29/14/3383

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