Two different isoforms of osteopontin modulate myelination and axonal integrity

Two different isoforms of osteopontin modulate myelination and axonal integrity

Abstract Abnormal myelination underlies the pathology of white matter diseases such as preterm white matter injury and multiple sclerosis. Osteopontin (OPN) has been suggested to play a role in myelination. Murine OPN mRNA is translated into a secreted isoform (sOPN) or an intracellular isoform (iOP...

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Bibliographic Details
Main Authors: Gisela Nilsson, Amin Mottahedin, Aura Zelco, Volker M. Lauschke, C. Joakim Ek, Juan Song, Maryam Ardalan, Sha Hua, Xiaoli Zhang, Carina Mallard, Henrik Hagberg, Jianmei W. Leavenworth, Xiaoyang Wang
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:FASEB BioAdvances
Subjects:
myelin
oligodendrocytes
osteopontin isoforms
RNA‐sequencing
Online Access:https://doi.org/10.1096/fba.2023-00030

Internet

https://doi.org/10.1096/fba.2023-00030

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