Three-Component Reaction of Diamines with Triethyl Orthoformate and Diethyl Phosphite and Anti-Proliferative and Antiosteoporotic Activities of the Products

Three-Component Reaction of Diamines with Triethyl Orthoformate and Diethyl Phosphite and Anti-Proliferative and Antiosteoporotic Activities of the Products

A three-component reaction between diamines (diaminobenzenes, diaminocyclohexanes, and piperazines), triethyl orthoformate, and diethyl phosphite was studied in some detail. In the case of 1,3- and 1,4-diamines and piperazines, products of the substitution of two amino moieties—the corresp...

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Bibliographic Details
Main Authors: Patrycja Petruczynik, Paweł Kafarski, Mateusz Psurski, Joanna Wietrzyk, Zdzisław Kiełbowicz, Jan Kuryszko, Ewa Chmielewska
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
bisphosphonic acids
synthesis of c-p bond
multicomponent reactions
p-containing drugs
anti-proliferative activity
osteoclasts
in vivo activity
Online Access:https://www.mdpi.com/1420-3049/25/6/1424

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https://www.mdpi.com/1420-3049/25/6/1424

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