The structure of MadC from Clostridium maddingley reveals new insights into class I lanthipeptide cyclases

The structure of MadC from Clostridium maddingley reveals new insights into class I lanthipeptide cyclases

The rapid emergence of microbial multi-resistance against antibiotics has led to intense search for alternatives. One of these alternatives are ribosomally synthesized and post-translationally modified peptides (RiPPs), especially lantibiotics. They are active in a low nanomolar range and their high...

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Bibliographic Details
Main Authors: C. Vivien Knospe, Michael Kamel, Olivia Spitz, Astrid Hoeppner, Stefanie Galle, Jens Reiners, Alexej Kedrov, Sander H. J. Smits, Lutz Schmitt
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Microbiology
Subjects:
lanthipeptide
cyclases
X-ray structure
class I lantibiotic
ITC
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1057217/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.1057217/full

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