AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation

AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation

Abstract Background Phosphoinositide-3 kinase (PI3K)/AKT signaling participates in cellular proliferation, survival and tumorigenesis. The activation of AKT signaling promotes the cellular reprogramming including generation of induced pluripotent stem cells (iPSCs) and dedifferentiation of primordia...

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Bibliographic Details
Main Authors: Yoichi Sekita, Yuki Sugiura, Akari Matsumoto, Yuki Kawasaki, Kazuya Akasaka, Ryo Konno, Momoka Shimizu, Toshiaki Ito, Eiji Sugiyama, Terushi Yamazaki, Eriko Kanai, Toshinobu Nakamura, Makoto Suematsu, Fumitoshi Ishino, Yoshio Kodera, Takashi Kohda, Tohru Kimura
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Stem Cell Research & Therapy
Subjects:
AKT signal
TET
αKG
DNA demethylation
Reprogramming
iPS cells
Online Access:https://doi.org/10.1186/s13287-021-02578-1

Internet

https://doi.org/10.1186/s13287-021-02578-1

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