Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo

Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo

Pancreatic cancer, one of the most aggressive malignancies, has no effective treatment due to the lack of targets and drugs related to tumour metastasis. SIRT6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic cancer. However, highly sele...

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Bibliographic Details
Main Authors: Xinyuan Xu, Qian Zhang, Xufeng Wang, Jing Jin, Chengwei Wu, Li Feng, Xiuyan Yang, Mingzhu Zhao, Yingyi Chen, Shaoyong Lu, Zhen Zheng, Xiaobing Lan, Yi Wang, Yan Zheng, Xuefeng Lu, Qiufen Zhang, Jian Zhang
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
SIRT6
Inhibitor
Allosteric
Selectivity
Cocrystal
Pancreatic cancer metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523004379

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http://www.sciencedirect.com/science/article/pii/S2211383523004379

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